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1 ). Moreover KS, a multicentric angio-proliferative disease predominantly of the pores and skin, KSHV an infection is linked to main effusion lymphoma (PEL) and to a subset of multicentric Castleman’s disease (MCD) (Waterston and Bower 2004 ; Carbone and Gloghini 2008 ). KS, PEL, and MCD are commonly associated with human immunodeficiency virus (HIV) infection, and these illnesses may co-exist (Cesarman and others 1995 ; Soulier and others 1995 ; Yarchoan and others 2005 ). KSHV-derived viral IL-6 (vIL-6) is detected in a proportion of KSHV-contaminated individuals (Aoki and others 2001b , 2001c ; Uldrick and others 2010 ). Like cellular IL-6, vIL-6 alerts by way of gp130 to activate the JAK-STAT pathway.

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